12 個(gè)首次披露的小分子在新藥研究領(lǐng)域的前景匯總

在落幕的 ACS Spring 2025 (美國(guó)化學(xué)會(huì)春季年會(huì)) 上，多個(gè)創(chuàng)新藥物首次披露，涵蓋了腫瘤、心血管、神經(jīng)系統(tǒng)疾病等多個(gè)領(lǐng)域。

這些小分子藥物代表了當(dāng)下最前沿的藥物化學(xué)設(shè)計(jì)趨勢(shì)。這些首次亮相的“新星”是否有望成為下一代重磅新藥？跟隨小 M 一起來看看它們的背景信息。

 
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小結(jié)

這 12 個(gè)首次亮相的小分子藥物，不僅展示了目前藥物研發(fā)的多樣化方向 (從傳統(tǒng)抑制劑到蛋白降解劑、共價(jià)靶向劑、大環(huán)肽等)，也反映出精準(zhǔn)醫(yī)療背景下對(duì)突變蛋白、腫瘤微環(huán)境、腦部靶點(diǎn)等復(fù)雜機(jī)制的深入探索。部分分子已經(jīng)進(jìn)入臨床階段，值得持續(xù)關(guān)注。
 

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