Hepcidin-25的作用機制及在炎癥、心血管與腫瘤等動物模型中的應用

Hepcidin-25是一種由25個氨基酸組成的肽類激素，在其肽鏈中存在著一條金屬結合基序，并在脊椎動物鐵代謝調控中發揮核心作用¹。作為鐵穩態的"主調控因子"，它通過抑制腸道鐵吸收和巨噬細胞鐵釋放來調控循環鐵的水平²。Hepcidin-25常常作為疾病模型中的分析指標或者生物標志分子。例如在健康狀態下，大鼠血漿中Hepcidin-25的平均濃度為63.0 ng/mL，而在脂多糖刺激后顯著升高至218.2 ng/mL，表明Hepcidin-25與炎癥反應高度相關³。在心血管領域，研究發現Hepcidin-25與動脈僵硬度存在關聯⁴。Hepcidin-25還可調節鐵代謝，Hepcidin-25與其受體鐵輸出蛋白結合后，可抑制腸道鐵吸收以及肝細胞和巨噬細胞的鐵外排。檢測Hepcidin-25可以預測機體的鐵代謝狀態，并有助于研究貧血和某些以貧血為特征的動物疾病模型，例如慢性腎臟�。–KD）、糖尿病相關的慢性腎病、炎癥性腸病血色病等動物模型⁵。Hepcidin-25的升高還可用于監測腫瘤的發生發展，例如Hepcidin-25與肝細胞癌的腎臟轉移有關⁶，并且Hepcidin-25還可作為非侵入性乳腺癌預測工具。目前針對Hepcidin-25的檢測手段包括LC-MS/MS法、ELISA檢測試劑盒等技術。Hepcidin-25還具有其它的生物學應用例如抗菌，有研究表明Hepcidin-25的水平在細菌感染后會明顯上調，表明其與機體的主動防御有關。而在體外實驗中，Hepcidin-25及其衍生物Hepcidin-20對多種病原微生物表現出抑制活性⁷。
 
參考文獻及鳴謝
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